A network perspective on metabolism and aging.
نویسندگان
چکیده
Aging affects a myriad of genetic, biochemical, and metabolic processes, and efforts to understand the underlying molecular basis of aging are often thwarted by the complexity of the aging process. By taking a systems biology approach, network analysis is well-suited to study the decline in function with age. Network analysis has already been utilized in describing other complex processes such as development, evolution, and robustness. Networks of gene expression and protein-protein interaction have provided valuable insight into the loss of connectivity and network structure throughout lifespan. Here, we advocate the use of metabolic networks to expand the work from genomics and proteomics. As metabolism is the final fingerprint of functionality and has been implicated in multiple theories of aging, metabolomic methods combined with metabolite network analyses should pave the way to investigate how relationships of metabolites change with age and how these interactions affect phenotype and function of the aging individual. The metabolomic network approaches highlighted in this review are fundamental for an understanding of systematic declines and of failure to function with age.
منابع مشابه
Integration of the Existed Knowledge on DMN: A Critical Review Study
The default-mode network (DMN) is one of the human brain’s networks activated in resting and self-referential thinking states. The nature of this network and its normal or abnormal changes has been the subject of various studies. The aim of this study was to systematical review and integrating the findings of that studies focused on the relationship of DMN with mental disorders and aging-induce...
متن کاملConcepts and Images of Aging From the Perspective of Psychological Components in the Curriculum of the Primary School of the Iranian Educational System: Qualitative Content Analysis
Objectives The present study aims to analyze the content of primary school textbooks in the Iranian educational system based on the psychological components of the elderly and how these books have reproduced the psychological components of the elderly. Methods & Materials The research method was descriptive-content analysis. The statistical population of the study included primary school textb...
متن کاملMulti-perspective Decision Support System for Hierarchical Bus Transportation Network Design: Tehran Case Study
In this paper, a multi-perspective decision support system (MP-DSS) to design hierarchical public transportation network is developed. Since this problem depends on different perspectives, MP-DSS consists of two sub-systems with macro and micro sub-systems based on travel information, land use and expert knowledge. In the micro sub-system, two sub-modules are developed considering o...
متن کاملThe multilevel analysis of the social network in the older adults on the Urban HEART-2
Background: Social network in older adults refers to the interpersonal relationships and the perception of these relationships. Given the importance of the social network, the current study was conducted to answer three pivotal questions. First, do personal and district factors affect the social network of the elderly? Second, how much share do the personal and district factors have in the soci...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Integrative and comparative biology
دوره 50 5 شماره
صفحات -
تاریخ انتشار 2010